A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

Abstract

In hospitalized adult patients with severe Covid-19, no benefit was observed with lopinavir-ritonavir treatment beyond standard care. Future trials in patients with severe illness may help to confirm or exclude the possibility of a treatment benefit. (Funded by Major Projects of National Science and Technology on New Drug Creation and Development and others; Chinese Clinical Trial Register number, ChiCTR2000029308.).

Keywords

LopinavirMedicineRitonavirLopinavir/ritonavirConfidence intervalHazard ratioRandomizationRandomized controlled trialInternal medicineAnesthesiaCoronavirus disease 2019 (COVID-19)Viral loadHuman immunodeficiency virus (HIV)ImmunologyDisease

MeSH Terms

AdultAgedAntiviral AgentsBetacoronavirusCOVID-19COVID-19 TestingClinical Laboratory TechniquesCoronavirus InfectionsCytochrome P-450 CYP3A InhibitorsDrug TherapyCombinationFemaleHospital MortalityHumansIntention to Treat AnalysisLopinavirMaleMiddle AgedPandemicsPatient AcuityPneumoniaViralProportional Hazards ModelsReverse Transcriptase Polymerase Chain ReactionRitonavirSARS-CoV-2Time-to-TreatmentTreatment FailureViral Load

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Publication Info

Year: 2020
Type: article
Volume: 382
Issue: 19
Pages: 1787-1799
Citations: 5444
Access: Closed

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APA Style

                            
                                
                                    Bin Cao, 
                                
                                    Yeming Wang, 
                                
                                    Danning Wen
                                
                                et al.
                            
                            (2020). 
                            A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19. 
                            New England Journal of Medicine
                            , 382
                            (19)
                            , 1787-1799.
                            https://doi.org/10.1056/nejmoa2001282
                        

Identifiers

DOI: 10.1056/nejmoa2001282
PMID: 32187464
PMCID: PMC7121492

Data Quality

Data completeness: 86%