A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains

Abstract

Voxel-based-morphometry (VBM) is a whole-brain, unbiased technique for characterizing regional cerebral volume and tissue concentration differences in structural magnetic resonance images. We describe an optimized method of VBM to examine the effects of age on grey and white matter and CSF in 465 normal adults. Global grey matter volume decreased linearly with age, with a significantly steeper decline in males. Local areas of accelerated loss were observed bilaterally in the insula, superior parietal gyri, central sulci, and cingulate sulci. Areas exhibiting little or no age effect (relative preservation) were noted in the amygdala, hippocampi, and entorhinal cortex. Global white matter did not decline with age, but local areas of relative accelerated loss and preservation were seen. There was no interaction of age with sex for regionally specific effects. These results corroborate previous reports and indicate that VBM is a useful technique for studying structural brain correlates of ageing through life in humans.

Keywords

Grey matterVoxelVoxel-based morphometryWhite matterInsulaAgeingEntorhinal cortexAmygdalaCingulate cortexBrain morphometryHuman brainPsychologyCortex (anatomy)Magnetic resonance imagingNeuroscienceAnatomyBiologyMedicineHippocampusCentral nervous systemInternal medicineRadiology

MeSH Terms

AdolescentAdultAgedAgingAtrophyBrainBrain MappingCephalometryDominanceCerebralFemaleHumansImage EnhancementImage ProcessingComputer-AssistedMagnetic Resonance ImagingMaleMiddle AgedReference ValuesSex Factors

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Publication Info

Year: 2001
Type: article
Volume: 14
Issue: 1
Pages: 21-36
Citations: 4546
Access: Closed

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APA Style

                            
                                
                                    Catriona D. Good, 
                                
                                    Ingrid S. Johnsrude, 
                                
                                    John Ashburner
                                
                                et al.
                            
                            (2001). 
                            A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains. 
                            NeuroImage
                            , 14
                            (1)
                            , 21-36.
                            https://doi.org/10.1006/nimg.2001.0786
                        

Identifiers

DOI: 10.1006/nimg.2001.0786
PMID: 11525331

Data Quality

Data completeness: 86%