Keywords
BiologyDrug resistanceTyrosine kinaseAcquired resistanceDrugCancerTyrosine-kinase inhibitorPharmacologyKinaseReceptor tyrosine kinaseCancer researchCancer therapySignal transductionBiochemistryGenetics
Affiliated Institutions
Related Publications
Diagnosing and Managing Advanced Chronic Myeloid Leukemia
Clinical staging of chronic myeloid leukemia (CML) distinguishes between chronic phase (CP-CML), accelerated phase (AP-CML), and blastic phase (BP-CML), reflecting its natural h...
Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions
Over 90% of all cancers are carcinomas, malignancies derived from cells of epithelial origin. As carcinomas progress, these tumors may lose epithelial morphology and acquire mes...
Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management
Disease overview : Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm with an incidence of 1–2 cases per 100,000 adults, and accounts for ∼15% of newly diagnosed ca...
Oncogenic<i>CSF3R</i>Mutations in Chronic Neutrophilic Leukemia and Atypical CML
Mutations in CSF3R are common in patients with CNL or atypical CML and represent a potentially useful criterion for diagnosing these neoplasms. (Funded by the Leukemia and Lymph...
Publication Info
- Year
- 2008
- Type
- review
- Volume
- 18
- Issue
- 1
- Pages
- 73-79
- Citations
- 283
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
283
OpenAlex
Cite This
Jeffrey A. Engelman,
Jeffrey Settleman
(2008).
Acquired resistance to tyrosine kinase inhibitors during cancer therapy.
Current Opinion in Genetics & Development
, 18
(1)
, 73-79.
https://doi.org/10.1016/j.gde.2008.01.004
Identifiers
- DOI
- 10.1016/j.gde.2008.01.004