Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles

Andreas Goette; Alicja Bukowska; Dobromir Dobrev; Jan Pfeiffenberger; Henning Morawietz; D. Strugala; Ingrid Wiswedel; Friedrich W. Röhl; Carmen Wolke; S. Bergmann; Peter Bramlage; Ursula Ravens; Uwe Lendeckel

doi:10.1093/eurheartj/ehp046

Abstract

Rapid atrial pacing induces AT(1)-receptor-mediated oxidative stress in LV myocardium that is accompanied by impaired microvascular blood flow and cTn-I release. These findings provide a plausible mechanism for the frequently observed cTn-I elevation accompanied with typical angina pectoris symptoms in patients with paroxysmal AF and normal (non-stenotic) coronary arteries.

Keywords

MedicineCardiologyInternal medicineMyocardial infarctionCoronary artery diseaseAtrial fibrillationAngina

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Publication Info

Year: 2009
Type: article
Volume: 30
Issue: 11
Pages: 1411-1420
Citations: 133
Access: Closed

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APA Style

                            
                                
                                    Andreas Goette, 
                                
                                    Alicja Bukowska, 
                                
                                    Dobromir Dobrev
                                
                                et al.
                            
                            (2009). 
                            Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles. 
                            European Heart Journal
                            , 30
                            (11)
                            , 1411-1420.
                            https://doi.org/10.1093/eurheartj/ehp046
                        

Identifiers

DOI: 10.1093/eurheartj/ehp046