Abstract
Tumor necrosis factor-α (TNF-α) has been shown to have certain catabolic effects on fat cells and whole animals. An induction of TNF-α messenger RNA expression was observed in adipose tissue from four different rodent models of obesity and diabetes. TNF-α protein was also elevated locally and systemically. Neutralization of TNF-α in obese fa / fa rats caused a significant increase in the peripheral uptake of glucose in response to insulin. These results indicate a role for TNF-α in obesity and particularly in the insulin resistance and diabetes that often accompany obesity.
Keywords
Tumor necrosis factor alphaAdipose tissueInsulin resistanceEndocrinologyInternal medicineObesityDiabetes mellitusInsulinBiologyInflammationType 2 diabetesMedicine
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Publication Info
- Year
- 1993
- Type
- article
- Volume
- 259
- Issue
- 5091
- Pages
- 87-91
- Citations
- 7345
- Access
- Closed
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Cite This
Gökhan S. Hotamışlıgil,
Narinder S. Shargill,
Bruce M. Spiegelman
(1993).
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance.
Science
, 259
(5091)
, 87-91.
https://doi.org/10.1126/science.7678183
Identifiers
- DOI
- 10.1126/science.7678183