Keywords
BiologyGenomeComputational biologyGenomicsCancer genome sequencingDNA sequencingExomeCancerExome sequencingGeneticsGeneMutation
Affiliated Institutions
Related Publications
Environmental exposures and mutational patterns of cancer genomes
The etiology of most human cancers is unknown. Genetic inheritance and environmental factors are thought to have major roles, and for some types of cancer, exposure to carcinoge...
The mutational constraint spectrum quantified from variation in 141,456 humans
Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences of gene disruption: genes that are crucial for the f...
Algorithmic challenges in mammalian whole‐genome assembly
Abstract Sequencing of the human, mouse, and rat genomes was accomplished more quickly than had seemed feasible a mere eight years ago. The accelerating pace of sequencing has b...
Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes
A Deep Look Into Our Genes Recent debates have focused on the degree of genetic variation and its impact upon health at the genomic level in humans (see the Perspective by Casal...
Publication Info
- Year
- 2010
- Type
- review
- Volume
- 11
- Issue
- 10
- Pages
- 685-696
- Citations
- 1104
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1104
OpenAlex
Cite This
Matthew Meyerson,
Stacey Gabriel,
Gad Getz
(2010).
Advances in understanding cancer genomes through second-generation sequencing.
Nature Reviews Genetics
, 11
(10)
, 685-696.
https://doi.org/10.1038/nrg2841
Identifiers
- DOI
- 10.1038/nrg2841