Age-Adjusted Standards for Creatinine Clearance

Abstract

Letters1 May 1976Age-Adjusted Standards for Creatinine ClearanceJOHN W. ROWE, M.D., REUBIN ANDRES, M.D., JORDAN D. TOBIN, M.D., ARTHUR H. NORRIS, M.S., NATHAN W. SHOCK, PH.D.JOHN W. ROWE, M.D.Search for more papers by this author, REUBIN ANDRES, M.D.Search for more papers by this author, JORDAN D. TOBIN, M.D.Search for more papers by this author, ARTHUR H. NORRIS, M.S.Search for more papers by this author, NATHAN W. SHOCK, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-5-567 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGlomerular filtration rate (GFR) has been shown to decline with age after maturity (1). Creatinine clearance finds frequent use as a clinical estimate of GFR, and published criteria for severity of renal disease include classification of patients according to their creatinine clearance as compared with the "predicted normal" (2). In spite of this recommendation, no satisfactory age-adjusted normal standards for creatinine clearance are currently available. The present study was done in order to provide such standards.Standard 24-h creatinine clearance measurements were done on 884 adult male subjects (17 to 96 years) in the Baltimore Longitudinal Study of Aging (3)....References1. WESSON L: Renal hemodynamics in physiological states, in Physiology of the Human Kidney, edited in WESSON LG JR, New York, Grune and Stratton, 1969, p. 96 Google Scholar2. : Criteria for the evaluation of the severity of established renal disease. Ann Intern Med 75:251-252, 1971 LinkGoogle Scholar3. STONENORRIS JA: Activities and attitudes of participants in the Baltimore Longitudinal Study. J Gerontol 21:575-580, 1966 CrossrefMedlineGoogle Scholar4. HEALY J: Clinical assessment of glomerular filtration rate by different forms of creatinine clearance and a modified urinary phenolsulphonphthalein excretion test. Am J Med 44:348-358, 1968 CrossrefMedlineGoogle Scholar5. SIERSBAEK-NIELSENMOLHOLM HANSENKAMPMANN KJJ: Rapid evaluation of creatinine clearance. Lancet 1:1133-1134, 1971 CrossrefMedlineGoogle Scholar6. GAULCOCKCROFT MD: Creatinine clearance and age. Lancet 2:613-614, 1975 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN W. ROWE, M.D.; REUBIN ANDRES, M.D.; JORDAN D. TOBIN, M.D.; ARTHUR H. NORRIS, M.S.; NATHAN W. 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