Abstract
These are the first human data to show that use of the aldosterone antagonist, spironolactone, can positively improve time-domain heart rate variability and reduce myocardial collagen turnover, as reflected by further reductions in serum procollagen peptide, despite concurrent ACE inhibitor treatment. Residual aldosterone after ACE inhibitor treatment may therefore have a role promoting arrhythmia and cardiac death by two mechanisms. Effects of additional spironolactone on slowing heart rate (and potentially the detrimental effect of aldosterone) were most prominent between 6 a.m. and 10 a.m. when cardiac death is also known to be most prominent.
Keywords
SpironolactoneInternal medicineAldosteroneHeart failureMedicineEndocrinologyHeart rateHeart rate variabilityCardiologyBlood pressure
MeSH Terms
AgedAngiotensin-Converting Enzyme InhibitorsBiomarkersCircadian RhythmDiureticsDouble-Blind MethodDrug TherapyCombinationElectrocardiographyAmbulatoryFemaleFibrosisHeart FailureHeart RateHumansMaleMineralocorticoid Receptor AntagonistsMyocardiumPeptide FragmentsProcollagenSpironolactone
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Publication Info
- Year
- 1997
- Type
- article
- Volume
- 35
- Issue
- 1
- Pages
- 30-34
- Citations
- 337
- Access
- Closed
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Cite This
R. MacFadyen
(1997).
Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients.
Cardiovascular Research
, 35
(1)
, 30-34.
https://doi.org/10.1016/s0008-6363(97)00091-6
Identifiers
- DOI
- 10.1016/s0008-6363(97)00091-6
- PMID
- 9302344