Abstract
Various species of Streptomyces possess aminoglycoside-modifying enzymes. Streptomyces kanamyceticus contains an enzyme that acetylates the 6′-amino group of kanamycin A and B, gentamicin C 1a , and neomycin. Streptomyces spectabilis produces an enzyme that acetylates the 2′-amino group of the hexose ring of gentamicin C 1a . These enzymes catalyze reactions identical to those catalyzed by enzymes found in gram-negative bacteria containing R(antibiotic resistance)-factors. The discovery of these enzymes suggests the possibility of an evolutionary relationship between the aminoglycosideinactivating enzymes (produced by resistance determinants) in bacteria containing R-factors and similar enzymes found in the actinomycetes.
Keywords
EnzymeStreptomycesKanamycinAminoglycosideBacteriaAntibioticsMicrobiologyNeomycinGentamicinBiologyBiochemistryGenetics
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Publication Info
- Year
- 1973
- Type
- article
- Volume
- 70
- Issue
- 8
- Pages
- 2276-2280
- Citations
- 503
- Access
- Closed
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Cite This
Raoul Ė. Benveniste,
Julian Davies
(1973).
Aminoglycoside Antibiotic-Inactivating Enzymes in Actinomycetes Similar to Those Present in Clinical Isolates of Antibiotic-Resistant Bacteria.
Proceedings of the National Academy of Sciences
, 70
(8)
, 2276-2280.
https://doi.org/10.1073/pnas.70.8.2276
Identifiers
- DOI
- 10.1073/pnas.70.8.2276