Abstract

The amyloid β protein has been identified as an important component of both cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome. A complementary DNA for the β protein suggests that it derives from a larger protein expressed in a variety of tissues. Overexpression of the gene in brain tissue from fetuses with Down syndrome (trisomy 21) can be explained by dosage since the locus encoding the β protein maps to chromosome 21. Regional localization of this gene by both physical and genetic mapping places it in the vicinity of the genetic defect causing the inherited form of Alzheimer's disease.

Keywords

Locus (genetics)GeneBACE1-ASBiologyComplementary DNAChromosome 21Alzheimer's diseaseDown syndromeTrisomyGeneticsAmyloid precursor proteinGene mappingAmyloid (mycology)Genetic linkageMolecular biologyChromosomeDiseasePathologyMedicine

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Publication Info

Year
1987
Type
article
Volume
235
Issue
4791
Pages
880-884
Citations
1595
Access
Closed

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Rudolph E. Tanzi, James F. Gusella, Paul C. Watkins et al. (1987). Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus. Science , 235 (4791) , 880-884. https://doi.org/10.1126/science.2949367

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DOI
10.1126/science.2949367