An Essential Role for Ectodomain Shedding in Mammalian Development

Jacques J. Peschon; Jennifer L. Slack; P. Linga Reddy; Kim L. Stocking; Susan W. Sunnarborg; David C. Lee; William E. Russell; Beverly J. Castner; Richard S. Johnson; Jeffrey N. Fitzner; Rogely Boyce; Nicole Nelson; Carl J. Kozlosky; Martin F. Wolfson; Charles T. Rauch; Douglas Pat Cerretti; Raymond J. Paxton; Carl J. March; Roy A. Black

doi:10.1126/science.282.5392.1281

Abstract

The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis factor-α converting enzyme (TACE), has been identified only in the case when tumor necrosis factor-α (TNFα) is released. Analyses of cells lacking this metalloproteinase-disintegrin revealed an expanded role for TACE in the processing of other cell surface proteins, including a TNF receptor, the l -selectin adhesion molecule, and transforming growth factor-α (TGFα). The phenotype of mice lacking TACE suggests an essential role for soluble TGFα in normal development and emphasizes the importance of protein ectodomain shedding in vivo.

Keywords

EctodomainDisintegrinMetalloproteinaseTumor necrosis factor alphaCell biologyProteolysisBiologyTransforming growth factorReceptorPhenotypeCell adhesionProteaseCellMatrix metalloproteinaseImmunologyEnzymeBiochemistry

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Publication Info

Year: 1998
Type: article
Volume: 282
Issue: 5392
Pages: 1281-1284
Citations: 1598
Access: Closed

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APA Style

                            
                                
                                    Jacques J. Peschon, 
                                
                                    Jennifer L. Slack, 
                                
                                    P. Linga Reddy
                                
                                et al.
                            
                            (1998). 
                            An Essential Role for Ectodomain Shedding in Mammalian Development. 
                            Science
                            , 282
                            (5392)
                            , 1281-1284.
                            https://doi.org/10.1126/science.282.5392.1281
                        

Identifiers

DOI: 10.1126/science.282.5392.1281