An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

Timothy P. Sheahan; Amy Sims; Shuntai Zhou; Rachel L. Graham; Andrea J. Pruijssers; Maria L. Agostini; Sarah R. Leist; Alexandra Schäfer; Kenneth H. Dinnon; Laura J. Stevens; James D. Chappell; Xiaotao Lu; Tia M. Hughes; Amelia S. George; Collin S Hill; Stephanie A. Montgomery; Ariane J. Brown; Gregory R. Bluemling; Michael G. Natchus; Manohar Saindane; Alexander A. Kolykhalov; George R. Painter; Jennifer L. Harcourt; Azaibi Tamin; Natalie J. Thornburg; Ronald Swanstrom; Mark R. Denison; Ralph S. Baric

doi:10.1126/scitranslmed.abb5883

Abstract

A ribonucleoside analog inhibits SARS-CoV-2 in human airway epithelial cell cultures and SARS-CoV and MERS-CoV in mice.

Keywords

VirologyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)OutbreakCoronavirusVero cellBiology2019-20 coronavirus outbreakPandemicBioavailabilityPneumoniaMicrobiologyVirusMedicinePharmacologyDiseaseInfectious disease (medical specialty)Pathology

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Publication Info

Year: 2020
Type: article
Volume: 12
Issue: 541
Citations: 1132
Access: Closed

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APA Style

                            
                                
                                    Timothy P. Sheahan, 
                                
                                    Amy Sims, 
                                
                                    Shuntai Zhou
                                
                                et al.
                            
                            (2020). 
                            An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. 
                            Science Translational Medicine
                            , 12
                            (541)
                            .
                            https://doi.org/10.1126/scitranslmed.abb5883
                        

Identifiers

DOI: 10.1126/scitranslmed.abb5883