Abstract

Abstract MicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in posttranscriptional regulation of gene expression. They are powerful regulators of various cellular activities including cell growth, differentiation, development, and apoptosis. They have been linked to many diseases, and currently miRNA‐mediated clinical trial has shown promising results for treatment of cancer and viral infection. This review provides an overview and update on miRNAs biogenesis, regulation of miRNAs expression, their biological functions, and role of miRNAs in epigenetics and cell–cell communication. In addition, alteration of miRNAs following exercise, their association with diseases, and therapeutic potential will be explained. Finally, miRNA bioinformatics tools and conventional methods for miRNA detection and quantification will be discussed.

Keywords

microRNABiologyEpigeneticsComputational biologyRegulation of gene expressionFunction (biology)Gene expressionBiogenesisGene silencingGeneBioinformaticsGenetics

MeSH Terms

AnimalsCell CommunicationComputational BiologyEpigenesisGeneticExerciseGene Expression RegulationHigh-Throughput Nucleotide SequencingHumansMicroRNAsNeoplasmsSignal Transduction

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Publication Info

Year
2018
Type
review
Volume
234
Issue
5
Pages
5451-5465
Citations
1935
Access
Closed

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Cite This

Kioomars Saliminejad, Hamid Reza Khorram Khorshid, Shahrzad Soleymani Fard et al. (2018). An overview of microRNAs: Biology, functions, therapeutics, and analysis methods. Journal of Cellular Physiology , 234 (5) , 5451-5465. https://doi.org/10.1002/jcp.27486

Identifiers

DOI
10.1002/jcp.27486
PMID
30471116

Data Quality

Data completeness: 81%