Analysis of shared heritability in common disorders of the brain

Abstract

Brainstorming diseases Consistent classification of neuropsychiatric diseases is problematic because it can lead to misunderstanding of etiology. The Brainstorm Consortium examined multiple genome-wide association studies drawn from more than 200,000 patients for 25 brain-associated disorders and 17 phenotypes. Broadly, it appears that psychiatric and neurologic disorders share relatively little common genetic risk. However, different and independent pathways can result in similar clinical manifestations (e.g., psychosis, which occurs in both schizophrenia and Alzheimer's disease). Schizophrenia correlated with many psychiatric disorders, whereas the immunopathological affliction Crohn's disease did not, and posttraumatic stress syndrome was also largely independent of underlying traits. Essentially, the earlier the onset of a disorder, the more inheritable it appeared to be. Science , this issue p. eaap8757

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Affiliated Institutions

• Harvard University US
• Assistance Publique – Hôpitaux de Paris FR
• Hôpital Paul-Brousse FR
• University of Utah US
• Institute for Neurodegenerative Disorders US
• University Hospital of Basel CH
• University of Kentucky US
• Sorbonne Université FR
• Saarland University DE
• Universitat Internacional de Catalunya ES
• Medical Research Council GB
• Johannes Kepler University of Linz AT
• UK Dementia Research Institute GB
• Indiana University – Purdue University Indianapolis US
• Charité - Universitätsmedizin Berlin DE
• Duke University US
• Université de Montpellier FR
• Aristotle University of Thessaloniki GR
• University of California, Irvine US
• Kyoto University JP
• USF Health Byrd Alzheimer's Institute US
• Massachusetts Institute of Technology US
• Friedrich-Alexander-Universität Erlangen-Nürnberg DE
• University Hospital Bonn DE
• Columbia University US
• University of Basel CH
• Cardiff University GB
• Université de Lille FR
• Framingham Heart Study US
• King's College Hospital GB
• Hôpital Gui de Chauliac FR
• University of Cambridge GB
• Université Paris-Sud FR
• Emory University US
• Boston University US
• Neuropsychiatrie : Recherche Epidemiologique et Clinique FR
• Greek Association of Alzheimer's Disease and Related Disorders GR
• Cleveland Clinic US
• Children's Hospital of Philadelphia US
• Oslo University Hospital
• Bordeaux Population Health FR
• RIKEN Center for Integrative Medical Sciences JP
• University of Pittsburgh US
• Indiana University School of Medicine
• Stanford University US
• 23andMe (United States) US
• Institut Pasteur de Lille FR
• Université de Bordeaux FR
• University of Michigan US
• Pitié-Salpêtrière Hospital FR
• Université de Rouen Normandie FR
• University of Tartu EE
• Rush University US
• Centre National de Recherche en Génomique Humaine FR
• MRC Prion Unit GB
• Columbia University Irving Medical Center US
• UCLA Medical Center US
• University of California, Los Angeles US
• Trinity College Dublin IE
• Translational Genomics Research Institute US
• King's College London GB
• Harbor–UCLA Medical Center US
• University College London GB
• Brigham Young University US
• AXA Research Fund FR
• University of Toronto CA
• University of Bonn DE
• Lou Ruvo Brain Institute US
• Life & Brain (Germany) DE
• Banner Sun Health Research Institute US
• University of Pennsylvania US
• Broad Institute US
• Icahn School of Medicine at Mount Sinai US
• Leipzig University DE
• Ludwig-Maximilians-Universität München DE
• Massachusetts General Hospital US
• Centre National de la Recherche Scientifique FR
• Universitätsklinikum Erlangen DE
• Rush University Medical Center US
• New Jersey Institute of Technology US
• Fundació ACE ES
• Institute for Molecular Medicine Finland FI
• University of South Florida US
• QIMR Berghofer Medical Research Institute AU
• The Lundquist Institute US
• University of Helsinki FI
• Illumina (United States) US
• Queen's University Belfast GB
• Oregon Health & Science University US
• Commissariat à l'Énergie Atomique et aux Énergies Alternatives FR
• Brigham and Women's Hospital US
• LMU Klinikum DE
• University of New Mexico US
• The University of Texas Health Science Center at San Antonio US
• Occupational Cancer Research Centre CA
• Center for Autism and Related Disorders US
• Hôpital Broca FR
• University of Nottingham GB
• Erasmus University Rotterdam NL
• Dublin City University IE
• Inserm FR
• Kaiser Permanente Washington Health Research Institute US
• Alzheimer Precision Medicine
• University of Southern California US
• University of Washington US
• Washington University in St. Louis US

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