Abstract
Abstract The demand for animal cell derived products has stimulated the development of bioreactors in the last decade. Most of those developments allow a higher cell concentration to be achieved in the bioreactor than in the past, primarily by means of the continuous flow of culture medium and a mechanism of cell retention. The advantages and technological challenges of some of these developments are discussed. Lagging behind the bioreactor developments is the strategy for culture operation and optimization. The need for suitable kinetic models to describe animal cell growth is emphasized.
Keywords
BioreactorBiochemical engineeringLaggingProcess engineeringComputer scienceBiologyEngineeringMathematics
Affiliated Institutions
Related Publications
Pneumatically Agitated Bioreactors in Industrial and Environmental Bioprocessing: Hydrodynamics, Hydraulics, and Transport Phenomena
Major aspects of design and operation of pneumatically agitated bioreactors are reviewed. The focus is on considerations that are relevant to industrial practice. Airlift biorea...
Clean-in-place systems for industrial bioreactors: Design, validation and operation
Guidelines for design, validation and operation of clean-in-place systems for industrial fermentation plant are presented. Design of vessels, surface finishes, materials of cons...
Is It Time to Start Transitioning From 2D to 3D Cell Culture?
Cell culture is an important and necessary process in drug discovery, cancer research, as well as stem cell study. Most cells are currently cultured using two-dimensional (2D) m...
Cultivation of cell‐polymer cartilage implants in bioreactors
Abstract Cartilage implants for potential use in reconstructive or orthopedic surgery can be created by growing isolated cartilage cells (chondrocytes) in vitro on synthetic, bi...
Mass transfer in external‐loop airlift bioreactors using static mixers
Abstract The influence of static mixers on the overall gas‐liquid volumetric mass transfer coefficient ( K L a L ) was examined in an external‐loop type airlift bioreactor (appr...
Publication Info
- Year
- 1991
- Type
- article
- Volume
- 69
- Issue
- 2
- Pages
- 409-420
- Citations
- 49
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
49
OpenAlex
Cite This
Wei‐Shou Hu,
Madhusudan V. Peshwa
(1991).
Animal cell bioreactors — recent advances and challenges to scale‐up.
The Canadian Journal of Chemical Engineering
, 69
(2)
, 409-420.
https://doi.org/10.1002/cjce.5450690203
Identifiers
- DOI
- 10.1002/cjce.5450690203