Abstract

Small-molecule defense Small-peptide defense molecules are produced by most organisms to fend off invasion by bacteria. The antimicrobial peptides that we know about so far show substantial diversity, synergism, and alternative functions. Lazzaro et al. review our knowledge of the evolution and diversity of antimicrobial peptides, the rapid pharmacodynamics of which make them promising candidates for translational applications to complement efforts to overcome antibiotic resistance. Science , this issue p. eaau5480

Keywords

Antimicrobial peptidesBiologyMulticellular organismComputational biologyAntimicrobialAntibioticsAntibiotic resistancePopulationGeneGeneticsMicrobiologyMedicine

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Year
2020
Type
review
Volume
368
Issue
6490
Citations
978
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Brian P. Lazzaro, Michael Zasloff, Jens Rolff (2020). Antimicrobial peptides: Application informed by evolution. Science , 368 (6490) . https://doi.org/10.1126/science.aau5480

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DOI
10.1126/science.aau5480