Abstract
Serial imaging in patients with clinically isolated syndromes improved the positive predictive value, sensitivity, and specificity of MRI for the development of early multiple sclerosis and also identified patients at a lower risk of early multiple sclerosis than would have been expected from their abnormal baseline MRI. Selection of patients with clinically isolated syndromes for therapeutic intervention or clinical trials may benefit from serial MRI, to target those at greatest risk of early development of multiple sclerosis.
Keywords
Multiple sclerosisMedicineClinically isolated syndromeMagnetic resonance imagingPredictive valueMcDonald criteriaInternal medicinePredictive value of testsRadiologyPathologyImmunology
MeSH Terms
AdolescentAdultFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisRiskSyndromeTime Factors
Affiliated Institutions
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Publication Info
- Year
- 2001
- Type
- article
- Volume
- 70
- Issue
- 3
- Pages
- 390-393
- Citations
- 82
- Access
- Closed
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Cite This
P A Brex
(2001).
Assessing the risk of early multiple sclerosis in patients with clinically isolated syndromes: the role of a follow up MRI.
Journal of Neurology Neurosurgery & Psychiatry
, 70
(3)
, 390-393.
https://doi.org/10.1136/jnnp.70.3.390
Identifiers
- DOI
- 10.1136/jnnp.70.3.390
- PMID
- 11181865
- PMCID
- PMC1737265