Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions

Michael G. Silverman; Brian A. Ference; Canqing Yu; Stephen D. Wiviott; Robert P. Giugliano; Scott M. Grundy; Eugene Braunwald; Marc S. Sabatine

doi:10.1001/jama.2016.13985

Abstract

In this meta-regression analysis, the use of statin and nonstatin therapies that act via upregulation of LDL receptor expression to reduce LDL-C were associated with similar RRs of major vascular events per change in LDL-C. Lower achieved LDL-C levels were associated with lower rates of major coronary events.

Keywords

MedicineInternal medicineMyocardial infarctionRelative riskStroke (engine)Clinical trialAcute coronary syndromeCardiologyStatinMeta-analysisCholesterolConfidence interval

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Publication Info

Year: 2016
Type: review
Volume: 316
Issue: 12
Pages: 1289-1289
Citations: 1385
Access: Closed

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APA Style

                            
                                
                                    Michael G. Silverman, 
                                
                                    Brian A. Ference, 
                                
                                    Canqing Yu
                                
                                et al.
                            
                            (2016). 
                            Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions. 
                            JAMA
                            , 316
                            (12)
                            , 1289-1289.
                            https://doi.org/10.1001/jama.2016.13985
                        

Identifiers

DOI: 10.1001/jama.2016.13985