Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

Abstract

Type 2 diabetes (T2D) is a major comorbidity of COVID-19. However, the impact of blood glucose (BG) control on the degree of required medical interventions and on mortality in patients with COVID-19 and T2D remains uncertain. Thus, we performed a retrospective, multi-centered study of 7,337 cases of COVID-19 in Hubei Province, China, among which 952 had pre-existing T2D. We found that subjects with T2D required more medical interventions and had a significantly higher mortality (7.8% versus 2.7%; adjusted hazard ratio [HR], 1.49) and multiple organ injury than the non-diabetic individuals. Further, we found that well-controlled BG (glycemic variability within 3.9 to 10.0 mmol/L) was associated with markedly lower mortality compared to individuals with poorly controlled BG (upper limit of glycemic variability exceeding 10.0 mmol/L) (adjusted HR, 0.14) during hospitalization. These findings provide clinical evidence correlating improved glycemic control with better outcomes in patients with COVID-19 and pre-existing T2D.

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Affiliated Institutions

• Ezhou Central Hospital CN
• Suizhou Central Hospital CN
• First People’s Hospital of Jingmen CN
• Wuhan No. 7 Hospital CN
• First People's Hospital of Jingzhou CN
• Third Xiangya Hospital CN
• Xiangyang Central Hospital CN
• Xianning Central Hospital CN
• Renmin Hospital of Wuhan University CN
• Wuhan University CN
• Nantong University CN
• Guangdong Pharmaceutical University CN
• Jingzhou Central Hospital CN
• China Three Gorges University CN
• Central South University CN
• Wuhan Third Hospital CN
• Zhongnan Hospital of Wuhan University CN
• Yichang Central People's Hospital CN
• The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture CN
• Huanggang Central Hospital CN
• Yancheng First People's Hospital CN
• Huazhong University of Science and Technology CN
• Tongren Hospital CN
• Hubei University of Arts and Science CN
• Central Hospital of Wuhan CN

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