Keywords
Affiliated Institutions
Related Publications
Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data
ABSTRACT Genome‐wide association studies, which typically report regression coefficients summarizing the associations of many genetic variants with various traits, are potential...
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
Mendelian randomisation uses genetic variation as a natural experiment to investigate the causal relations between potentially modifiable risk factors and health outcomes in obs...
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
An adaption of Egger regression (which we call MR-Egger) can detect some violations of the standard instrumental variable assumptions, and provide an effect estimate which is no...
Calculating statistical power in Mendelian randomization studies
In Mendelian randomization (MR) studies, where genetic variants are used as proxy measures for an exposure trait of interest, obtaining adequate statistical power is frequently ...
Mendelian randomization studies: a review of the approaches used and the quality of reporting
Most MR studies either use the genotype as a proxy for exposure without further estimation or perform an IV analysis. The discussion of underlying assumptions and reporting of s...
Publication Info
- Year
- 2015
- Type
- article
- Volume
- 69
- Pages
- 208-216
- Citations
- 96
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1016/j.jclinepi.2015.08.001