Keywords
Affiliated Institutions
Related Publications
Brca2 (XRCC11) Deficiency Results in Radioresistant DNA Synthesis and a Higher Frequency of Spontaneous Deletions
We show here that the radiosensitive Chinese hamster cell mutant (V-C8) of group XRCC11 is defective in the breast cancer susceptibility gene Brca2. The very complex phenotype o...
The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin
Mutations in breast cancer tumor susceptibility genes, BRCA1 and BRCA2, predispose women to early onset breast cancer and other malignancies. The Brca genes are involved in mult...
Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein
How dividing mammalian cells overcome blocks to DNA replication by DNA damage, depleted nucleotide pools, or template-bound proteins is unclear. Here, we show that the response ...
Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
Cells with non-functional poly(ADP-ribose) polymerase (PARP-1) show increased levels of sister chromatid exchange, suggesting a hyper recombination phenotype in these cells. To ...
Induction of Homologous Recombination in Mammalian Chromosomes by Using the I-<i>Sce</i>I System of <i>Saccharomyces cerevisiae</i>
The mitochondrial intron-encoded endonuclease I-SceI of Saccharomyces cerevisiae has an 18-bp recognition sequence and, therefore, has a very low probability of cutting DNA, eve...
Publication Info
- Year
- 2001
- Type
- article
- Volume
- 7
- Issue
- 2
- Pages
- 263-272
- Citations
- 991
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1016/s1097-2765(01)00174-5