Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

Abstract

Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. In the tumor microenvironment, smoldering inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis, subversion of adaptive immunity, reduced response to hormones and chemotherapeutic agents. Recent data suggest that an additional mechanism involved in cancer-related inflammation (CRI) is induction of genetic instability by inflammatory mediators, leading to accumulation of random genetic alterations in cancer cells. In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark.

Keywords

InflammationCancerAngiogenesisCancer researchTumor microenvironmentMetastasisBiologyImmunologyCancer cellMedicineGenetics

Affiliated Institutions

Related Publications

Tumor Angiogenesis: Therapeutic Implications

Louis M. Sherwood , Edith E. Parris , Judah Folkman

THE growth of solid neoplasms is always accompanied by neovascularization. This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary s...

1971 New England Journal of Medicine 10030 citations

Immune Regulation of Cancer

Mary L. Disis

Innate and adaptive immune system cells play a major role in regulating the growth of cancer. Although it is commonly thought that an immune response localized to the tumor will...

2010 Journal of Clinical Oncology 480 citations

Hallmarks of Cancer: New Dimensions

Douglas Hanahan

Abstract The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying...

2022 Cancer Discovery 7899 citations

TIMER2.0 for analysis of tumor-infiltrating immune cells

Taiwen Li , Jingxin Fu , Zexian Zeng +5 more

Abstract Tumor progression and the efficacy of immunotherapy are strongly influenced by the composition and abundance of immune cells in the tumor microenvironment. Due to the l...

2020 Nucleic Acids Research 5297 citations

The biologic importance of tumor‐infiltrating lymphocytes

F. Stephen Hodi , Glenn Dranoff

Detailed pathologic analysis has delineated a close association between intratumoral CD 8 + cytotoxic T cells and favorable clinical outcomes in diverse cancers. Conversely, the...

2010 Journal of Cutaneous Pathology 55 citations

Publication Info

Year: 2009
Type: review
Volume: 30
Issue: 7
Pages: 1073-1081
Citations: 2813
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

2813

OpenAlex

Cite This

APA Style

                            
                                
                                    Francesco Colotta, 
                                
                                    Paola Allavena, 
                                
                                    Antonio Sica
                                
                                et al.
                            
                            (2009). 
                            Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. 
                            Carcinogenesis
                            , 30
                            (7)
                            , 1073-1081.
                            https://doi.org/10.1093/carcin/bgp127
                        

Identifiers

DOI: 10.1093/carcin/bgp127