Abstract
A porous anionic metal-organic framework, bio-MOF-1, constructed using adenine as a biomolecular building block is described. The porosity of this material is evaluated, its stability in biological buffers is studied, and its potential as a material for controlled drug release is investigated. Specifically, procainamide HCl is loaded into the pores of bio-MOF-1 using a simple cation exchange process. Exogenous cations from biological buffers are shown to affect the release of the adsorbed drug molecules.
Keywords
ChemistryPorosityZincAdsorptionMetal-organic frameworkMoleculeMetalChemical engineeringInorganic chemistryDrugProcainamideCombinatorial chemistryOrganic chemistryPharmacology
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Publication Info
- Year
- 2009
- Type
- article
- Volume
- 131
- Issue
- 24
- Pages
- 8376-8377
- Citations
- 1046
- Access
- Closed
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Cite This
Jihyun An,
Steven J. Geib,
Nathaniel L. Rosi
(2009).
Cation-Triggered Drug Release from a Porous Zinc−Adeninate Metal−Organic Framework.
Journal of the American Chemical Society
, 131
(24)
, 8376-8377.
https://doi.org/10.1021/ja902972w
Identifiers
- DOI
- 10.1021/ja902972w