Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides.

C. Frank Bennett; M Y Chiang; Huai En Huang Chan; J E Shoemaker; Christopher K. Mirabelli

doi:10.1016/s0026-895x(25)09229-6

Keywords

OligonucleotideCytoplasmCationic liposomeChemistryBiochemistryLiposomeBiologyBiophysicsMolecular biologyCell biologyTransfectionDNA

Affiliated Institutions

Ionis Pharmaceuticals (United States) US

Related Publications

Gene Transfer Optimization with Lipospermine-Coated DNA

F. Barthel , Jean-Serge Rémy , Jean‐Philippe Loeffler +1 more

Designed synthetic DNA carriers represent an attractive alternative to the widely used calcium phosphate gene transfer technique. In this context, we developed a class of nuclei...

1993 DNA and Cell Biology 69 citations

Intracellular disposition and metabolism of fluorescently-labled unmodified and modified oligouncleotides microijjected into mammalian cells

Tracey L. Fisher , Terry Terhorst , Xiaodong Cao +1 more

The intracellular distribution and metabolism of microinjected fluorescently-labeled oligonucleotides (ODNs) have been evaluated using confocal fluorescence microscopy. Fluoresc...

1993 Nucleic Acids Research 241 citations

Cyclic amphipathic peptide-DNA complexes mediate high-efficiency transfection of adherent mammalian cells.

Jean‐Yves Legendre , Francis C. Szoka

A DNA transfection protocol has been developed that makes use of the cyclic cationic amphipathic peptide gramicidin S and dioleoyl phosphatidylethanolamine. The DNA complex is f...

1993 Proceedings of the National Academy o... 96 citations

Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses.

Jean-Serge Rémy , Antoine Kichler , Viatcheslav A. Mordvinov +2 more

Optimal in vitro gene delivery with cationic lipids requires an excess of cationic charges with respect to DNA phosphates. In these conditions, in vivo delivery will be hampered...

1995 Proceedings of the National Academy o... 241 citations

A new DNA nanostructure, the G-wire, imaged by scanning probe microscopy

T. R. Marsh , James Vesenka , Eric Henderson

G-DNA is a polymorphic family of quadruple helical nucleic acid structures containing guanine tetrad motifs [G-quartets; Williamson, J.R., Raghuraman, M.K. and Cech, T.R. (1989)...

1995 Nucleic Acids Research 226 citations

Publication Info

Year: 1992
Type: article
Volume: 41
Issue: 6
Pages: 1023-1033
Citations: 616
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides.

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

616

OpenAlex

Cite This

APA Style

                            
                                
                                    C. Frank Bennett, 
                                
                                    M Y Chiang, 
                                
                                    Huai En Huang Chan
                                
                                et al.
                            
                            (1992). 
                            Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides.. 
                            Molecular Pharmacology
                            , 41
                            (6)
                            , 1023-1033.
                            https://doi.org/10.1016/s0026-895x(25)09229-6
                        

Identifiers

DOI: 10.1016/s0026-895x(25)09229-6