Abstract

AKT is involved in regulating both cell proliferation and apoptotic pathways; however, the primary effect with GSK690693 appears to be anti-proliferative in the cell lines and xenografts evaluated. Furthermore, these results indicate that anti-proliferative responses to GSK690693 in either 2-D culture or xenograft models may share common mechanisms within and across sensitive cell lines.

Keywords

Protein kinase BBiologySignal transductionTranscriptomePI3K/AKT/mTOR pathwayMechanism (biology)PhosphoproteomicsKinaseCancer researchComputational biologyCell growthCell biologyGene expressionGeneGeneticsProtein kinase AProtein phosphorylation

MeSH Terms

AnimalsAntigensCDAntineoplastic AgentsCell CycleCell LineTumorCell ProliferationCell SurvivalFemaleForkhead Box Protein O1Forkhead Box Protein O3Forkhead Transcription FactorsGene Expression ProfilingHumansMiceModelsBiologicalOxadiazolesPhosphoproteinsProtein Kinase InhibitorsProteomeProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-mycReceptorsTransferrinRetinoblastoma ProteinTranscriptionGeneticXenograft Model Antitumor Assays

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Publication Info

Year
2010
Type
article
Volume
11
Issue
1
Pages
419-419
Citations
36
Access
Closed

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Cite This

Rakesh Kumar, Stephen J. Blakemore, Catherine Ellis et al. (2010). Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693. BMC Genomics , 11 (1) , 419-419. https://doi.org/10.1186/1471-2164-11-419

Identifiers

DOI
10.1186/1471-2164-11-419
PMID
20604938
PMCID
PMC2996947

Data Quality

Data completeness: 86%