Abstract
Several mechanisms control discrimination between self and non-self, including the thymic deletion of autoreactive T cells and the induction of anergy in the periphery. In addition to these passive mechanisms, evidence has accumulated for the active suppression of autoreactivity by a population of regulatory or suppressor T cells that co-express CD4 and CD25 (the interleukin-2 receptor alpha-chain). CD4+ CD25+ T cells are powerful inhibitors of T-cell activation both in vivo and in vitro. The enhancement of suppressor-cell function might prove useful for the treatment of immune-mediated diseases, whereas the downregulation of these cells might be beneficial for the enhancement of the immunogenicity of vaccines that are specific for tumour antigens.
Keywords
IL-2 receptorSuppressorImmunogenicityImmunologyImmune systemDownregulation and upregulationBiologyCell biologyImmune tolerancePopulationAntigenT cellInterleukin 10MedicineGeneGenetics
MeSH Terms
AbataceptAnimalsAntigen-Presenting CellsAntigensCDAntigensDifferentiationCD4 AntigensCTLA-4 AntigenCytokinesHomeostasisHumansImmune ToleranceImmunoconjugatesIn Vitro TechniquesLymphocyte ActivationMiceModelsImmunologicalRatsReceptorsInterleukin-2T-LymphocytesRegulatoryThymus GlandTransforming Growth Factor beta
Affiliated Institutions
Related Publications
Breast cancer instructs dendritic cells to prime interleukin 13–secreting CD4+ T cells that facilitate tumor development
We previously reported (Bell, D., P. Chomarat, D. Broyles, G. Netto, G.M. Harb, S. Lebecque, J. Valladeau, J. Davoust, K.A. Palucka, and J. Banchereau. 1999. J. Exp. Med. 190: 1...
Intraepithelial CD8<sup>+</sup>tumor-infiltrating lymphocytes and a high CD8<sup>+</sup>/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
In a recent report, [Zhang et al. (2003) N. Engl. J. Med. 348, 203–213], the presence of CD3 + tumor-infiltrating lymphocytes (TILs) was found to correlate with improved surviva...
Interleukin-6 Receptor Blockade Selectively Reduces IL-21 Production by CD4 T Cells and IgG4 Autoantibodies in Rheumatoid Arthritis
Interleukin-6 (IL-6) levels are known to be increased in patients with rheumatoid arthritis (RA). Tocilizumab, a monoclonal antibody to the IL-6 receptor (IL-6R), reduces diseas...
Blockade of Interleukin-6 Signaling Suppresses Not Only Th17 but Also Interphotoreceptor Retinoid Binding Protein–Specific Th1 by Promoting Regulatory T Cells in Experimental Autoimmune Uveoretinitis
PURPOSE. Both Th17 and Th1 cells contribute to experimental autoimmune uveoretinitis (EAU). Interleukin-6 (IL-6) blockade inhibits Th17 differentiation in EAU and potently suppr...
Frequency of regulatory T cells in peripheral blood and in tumour‐infiltrating lymphocytes correlates with poor prognosis in renal cell carcinoma
What’s known on the subject? and What does the study add? Treg overexpression has been demonstrated in several neoplasms, including liver, breast, pancreas and melanoma, while i...
Publication Info
- Year
- 2002
- Type
- review
- Volume
- 2
- Issue
- 6
- Pages
- 389-400
- Citations
- 2102
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
2102
OpenAlex
95
Influential
1610
CrossRef
Cite This
Ethan M. Shevach
(2002).
CD4+CD25+ suppressor T cells: more questions than answers.
Nature reviews. Immunology
, 2
(6)
, 389-400.
https://doi.org/10.1038/nri821
Identifiers
- DOI
- 10.1038/nri821
- PMID
- 12093005