Cell Migration: Integrating Signals from Front to Back

Abstract

Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms underlying the major steps of migration and the signaling pathways that regulate them, and outlines recent advances investigating the nature of polarity in migrating cells and the pathways that establish it.

Keywords

Cell polarityCell migrationRegeneration (biology)MorphogenesisNeuroscienceBiologyEmbryonic stem cellCell biologyProcess (computing)Polarity (international relations)CellSignal transductionComputer scienceGeneticsGene

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Publication Info

Year: 2003
Type: review
Volume: 302
Issue: 5651
Pages: 1704-1709
Citations: 4882
Access: Closed

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APA Style

                            
                                
                                    Anne J. Ridley, 
                                
                                    Martin A. Schwartz, 
                                
                                    Keith Burridge
                                
                                et al.
                            
                            (2003). 
                            Cell Migration: Integrating Signals from Front to Back. 
                            Science
                            , 302
                            (5651)
                            , 1704-1709.
                            https://doi.org/10.1126/science.1092053
                        

Identifiers

DOI: 10.1126/science.1092053