Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Keywords

SenescenceTelomereCell biologyBiologyAgeingPhenotypeDNA damageCellular senescenceRegeneration (biology)GeneticsDNAGene

Affiliated Institutions

Related Publications

Hallmarks of aging: An expanding universe

Carlos López‐Otín , Marı́a A. Blasco , Linda Partridge +2 more

2023 Cell 4404 citations

Emerging roles of extracellular vesicles in cellular senescence and aging

Masaki Takasugi

Summary Cellular senescence is a cellular program that prevents the proliferation of cells at risk of neoplastic transformation. On the other hand, age‐related accumulation of s...

2018 Aging Cell 198 citations

Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence

Stéphane Ansieau , Jérémy Bastid , Agnès Doreau +13 more

2008 Cancer Cell 682 citations

let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein

Min Han , Paul W. Sternberg

1990 Cell 395 citations

Of Flies and Man:<i>Drosophila</i>as a Model for Human Complex Traits

Trudy F. C. Mackay , Robert R. H. Anholt

Understanding the genetic and environmental factors affecting human complex genetic traits and diseases is a major challenge because of many interacting genes with individually ...

2006 Annual Review of Genomics and Human G... 90 citations

Publication Info

Year: 2020
Type: review
Volume: 22
Issue: 2
Pages: 75-95
Citations: 1913
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1913

OpenAlex

Cite This

APA Style

                            
                                
                                    Raffaella Di Micco, 
                                
                                    Valery Krizhanovsky, 
                                
                                    Darren J. Baker
                                
                                et al.
                            
                            (2020). 
                            Cellular senescence in ageing: from mechanisms to therapeutic opportunities. 
                            Nature Reviews Molecular Cell Biology
                            , 22
                            (2)
                            , 75-95.
                            https://doi.org/10.1038/s41580-020-00314-w
                        

Identifiers

DOI: 10.1038/s41580-020-00314-w