Abstract

Abstract Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). Our observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying central nervous system involvement by SARS‐CoV‐2.

Keywords

CoronavirusRespiratory systemCentral nervous systemVirusVirologyMedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Severe acute respiratory syndromeCoronaviridaeImmunologyCoronavirus disease 2019 (COVID-19)PathologyInternal medicineDiseaseInfectious disease (medical specialty)

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Year
2020
Type
article
Volume
92
Issue
7
Pages
699-702
Citations
991
Access
Closed

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Alberto Paniz‐Mondolfi, Clare Bryce, Zachary Grimes et al. (2020). Central nervous system involvement by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). Journal of Medical Virology , 92 (7) , 699-702. https://doi.org/10.1002/jmv.25915

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DOI
10.1002/jmv.25915