Abstract

Ninety-seven chronic alcoholics, both impaired and unimpaired, without clinically evident liver disease, showed significantly more cerebral atrophy on computed tomography than age-matched neurologic controls. Age was the variable most highly correlated with cerebral atrophy measurements, and it accounted for most of the correlations between atrophy and functional impairment, except in the Wernicke-amnesic group. Analysis of the slopes of atrophy scores versus age showed a more rapid "rate" of development of cerebral atrophy in alcoholics compared with controls. There were no correlations between liver biopsy scores (51 cases), drinking history (47 cases), or dietary intake (39 cases) and cerebral atrophy measurements.

Keywords

AtrophyCerebral atrophyMedicineInternal medicinePathologyGastroenterologyCardiology

MeSH Terms

AdultAgedAlcoholismAtrophyBrain DiseasesFemaleHumansIntelligenceMaleMiddle AgedPsychological TestsTomographyX-Ray ComputedWechsler ScalesWernicke Encephalopathy

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Publication Info

Year
1981
Type
article
Volume
31
Issue
4
Pages
377-377
Citations
118
Access
Closed

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Peter L. Carlen, D. Adrian Wilkinson, George Wortzman et al. (1981). Cerebral atrophy and functional deficits in alcoholics without clinically apparent liver disease. Neurology , 31 (4) , 377-377. https://doi.org/10.1212/wnl.31.4.377

Identifiers

DOI
10.1212/wnl.31.4.377
PMID
7194430

Data Quality

Data completeness: 81%