Abstract

✓ A quantitative autoradiographic technique that utilizes carbon-14-aminoisobutyric acid ( 14 C-AIB) as a tracer was used to study alterations in cerebral microvascular permeability in 15 rats. Five were “sham-operated” controls and 10 underwent microsurgical, unilateral occlusion of the proximal middle cerebral artery (MCA). Histological changes indicative of focal cerebral ischemia were observed in only the latter 10 animals. These changes were confined to tissue normally perfused by the occluded MCA. After MCA occlusion, five animals were also subjected to transient halothane-induced hypotension (mean arterial blood pressure 50 mm Hg) for 20 to 30 minutes. Only in these five animals were blood-to-brain transfer constants (k i ) significantly increased (by approximately 100%) at 4 hours after MCA occlusion. The topographical distribution of this alteration in cerebral microvascular permeability corresponded closely with the histological changes. Neither proximal MCA occlusion nor halothane-induced hypotension alone was associated with any focal or diffuse increase in k i after 4 hours.

Keywords

MedicineOcclusionMiddle cerebral arteryHalothaneIschemiaAnesthesiaCerebral blood flowBlood flowAnatomyCardiology

Related Publications

Publication Info

Year
1982
Type
article
Volume
57
Issue
2
Pages
186-196
Citations
57
Access
Closed

External Links

View on DOI.org

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

57
OpenAlex

Cite This

George W. Tyson, Graham M. Teasdale, David I. Graham et al. (1982). Cerebrovascular permeability following MCA occlusion in the rat. Journal of neurosurgery , 57 (2) , 186-196. https://doi.org/10.3171/jns.1982.57.2.0186

Identifiers

DOI
10.3171/jns.1982.57.2.0186