Abstract

Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the β peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide. The 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus. The gene is highly conserved in evolution and has been mapped to human chromosome 21.

Keywords

Open reading frameComplementary DNABiologyAmino acidGeneBACE1-ASHuman brainPeptide sequenceAmyloid (mycology)cDNA libraryMolecular biologyclone (Java method)Chromosome 21Alzheimer's diseaseGeneticsOligonucleotideChromosomeDiseaseNeurosciencePathologyMedicine

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Publication Info

Year
1987
Type
article
Volume
235
Issue
4791
Pages
877-880
Citations
1319
Access
Closed

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Cite This

Dmitry Goldgaber, Michael I. Lerman, O. Wesley McBride et al. (1987). Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease. Science , 235 (4791) , 877-880. https://doi.org/10.1126/science.3810169

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DOI
10.1126/science.3810169