Abstract

Components of a signaling pathway that couples the ciliary neurotrophic factor (CNTF) receptor to induction of transcription were identified. CNTF stimulated the tyrosine phosphorylation of p91, a protein implicated in interferon signaling pathways, and of two proteins that are distinct but related to p91. Tyrosine-phosphorylated p91 translocated to the nucleus, where p91 and p91-related proteins bound to a DNA sequence found in promoters of genes responsive to CNTF. This DNA sequence, when inserted upstream of a reporter gene, conferred a transcriptional response to CNTF. A pathway that transduces interferon signals may therefore have a more general function in the propagation of responses to certain neurotrophic factors.

Keywords

Ciliary neurotrophic factorBiologyCell biologyTyrosine phosphorylationSignal transductionPhosphorylationTranscription factorNucleusNeurotrophic factorsGeneReceptorGenetics

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Publication Info

Year
1993
Type
article
Volume
262
Issue
5139
Pages
1575-1579
Citations
180
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Closed

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Azad Bonni, David A. Frank, Chris Schindler et al. (1993). Characterization of a Pathway for Ciliary Neurotrophic Factor Signaling to the Nucleus. Science , 262 (5139) , 1575-1579. https://doi.org/10.1126/science.7504325

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DOI
10.1126/science.7504325