Abstract
Langerhans' cells migrating from contact-sensitized skin were found to up-regulate expression of macrophage-derived chemokine (MDC) during maturation into lymph node dendritic cells (DCs). Naı̈ve T cells did not migrate toward MDC, but antigen-specific T cells rapidly acquired MDC responsiveness in vivo after a subcutaneous injection of antigen. In chemotaxis assays, maturing DCs attracted activated T cells more strongly than naı̈ve T cells. These studies identified chemokine up-regulation as part of the Langerhans' cell maturation program to immunogenic T cell–zone DC. Preferential recruitment of activated T cells may be a mechanism used by maturing DCs to promote encounters with antigen-specific T cells.
Keywords
Cell biologyChemokineAntigen-presenting cellDendritic cellT cellChemotaxisAntigenBiologyImmunologyChemistryImmune systemReceptor
MeSH Terms
AnimalsCellsCulturedChemokine CCL19Chemokine CCL22ChemokinesCCChemotaxisLeukocyteDendritic CellsDermatitisContactFluorescein-5-isothiocyanateLangerhans CellsLymph NodesLymphocyte ActivationMiceT-LymphocytesUp-Regulation
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Publication Info
- Year
- 1999
- Type
- article
- Volume
- 284
- Issue
- 5415
- Pages
- 819-822
- Citations
- 309
- Access
- Closed
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Cite This
Hao Tang,
Jason G. Cyster
(1999).
Chemokine Up-Regulation and Activated T Cell Attraction by Maturing Dendritic Cells.
Science
, 284
(5415)
, 819-822.
https://doi.org/10.1126/science.284.5415.819
Identifiers
- DOI
- 10.1126/science.284.5415.819
- PMID
- 10221917