Chemokines and chemokine receptors: an overview

Abstract

Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling activity. Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value.

Keywords

ChemokineChemokine receptorReceptorCCR1ChemotaxisCCR10CCL13Cell biologyCCL21CCR3BiologyImmunologyChemistryBiochemistry

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Publication Info

Year: 2009
Type: review
Volume: Volume
Issue: 14
Pages: 540-540
Citations: 247
Access: Closed

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APA Style

                            
                                
                                    Raffaella Bonecchi, 
                                
                                    Emanuela Galliera, 
                                
                                    Elena Monica Borroni
                                
                                et al.
                            
                            (2009). 
                            Chemokines and chemokine receptors: an overview. 
                            Frontiers in bioscience
                            , Volume
                            (14)
                            , 540-540.
                            https://doi.org/10.2741/3261
                        

Identifiers

DOI: 10.2741/3261