Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

Abstract

The cholesterol crystal-induced inflammasome activation in macrophages may represent an important link between cholesterol metabolism and inflammation in atherosclerotic lesions.

Keywords

InflammasomeInflammationSecretionCholesterolProinflammatory cytokineCaspase 1ChemistryCell biologyBiologyBiochemistryImmunology

Affiliated Institutions

Related Publications

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

Catherine Dostert , Virginie Pétrilli , Robin van Bruggen +3 more

The inhalation of airborne pollutants, such as asbestos or silica, is linked to inflammation of the lung, fibrosis, and lung cancer. How the presence of pathogenic dust is recog...

2008 Science 2616 citations

Human amyloid β‐induced neuroinflammation is an early event in neurodegeneration

Jeffrey M. Craft , D. Martin Watterson , Linda J. Van Eldik

Abstract Using a human amyloid β (Aβ) intracerebroventricular infusion mouse model of Alzheimer's disease‐related injury, we previously demonstrated that systemic administration...

2005 Glia 109 citations

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

Bharat B. Aggarwal , R. V. Vijayalekshmi , Bokyung Sung

Abstract Chronic infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and high-calorie diet have been recognized as major risk factors for the most common...

2009 Clinical Cancer Research 765 citations

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

Philippe Delerive , Karolien De Bosscher , Sandrine Besnard +7 more

Interleukin-6 (IL-6) is a pleiotropic cytokine, whose plasma levels are elevated in inflammatory diseases such as atherosclerosis. We have previously reported that peroxisome pr...

1999 Journal of Biological Chemistry 1062 citations

Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis

Eleni Karakike , Evangelos J. Giamarellos‐Bourboulis

Hemophagocytic lymphohistocytosis (HLH) is characterized by fulminant cytokine storm leading to multiple organ dysfunction and high mortality. HLH is classified into familial (f...

2019 Frontiers in Immunology 295 citations

Publication Info

Year: 2010
Type: article
Volume: 5
Issue: 7
Pages: e11765-e11765
Citations: 975
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

975

OpenAlex

Cite This

APA Style

                            
                                
                                    Kristiina Rajamäki, 
                                
                                    Jani Lappalainen, 
                                
                                    Katariina Öörni
                                
                                et al.
                            
                            (2010). 
                            Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation. 
                            PLoS ONE
                            , 5
                            (7)
                            , e11765-e11765.
                            https://doi.org/10.1371/journal.pone.0011765
                        

Identifiers

DOI: 10.1371/journal.pone.0011765