Abstract
β-Asarone is a characteristic component of the volatile oil of Acorus calamus. Effects on chromosomes were studied in human lymphocyte cultures as a result of treatment by β-asarone. The tests were performed with and without the addition of liver microsomes from rats. A very strong effect on the induction of structural chromosome aberrations was found after metabolic activation; multiple damaged cells occurred. In addition, a slight increase in the rate of sister chromatid exchanges (SCE) was observed. Our results demonstrate clearly the genotoxic potency of β-asarone and hence emphasize the demand that only acorus with low content of β-asarone should be used.
Keywords
MedicineChemistry
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Publication Info
- Year
- 1987
- Type
- article
- Volume
- 53
- Issue
- 03
- Pages
- 251-253
- Citations
- 63
- Access
- Closed
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Cite This
Gudrun Abel
(1987).
Chromosomenschädigende Wirkung von β-Asaron in menschlichen Lymphocyten.
Planta Medica
, 53
(03)
, 251-253.
https://doi.org/10.1055/s-2006-962694
Identifiers
- DOI
- 10.1055/s-2006-962694