Abstract
The chromosome constitution has been determined in 21 solid tumors—17 primary and 4 metastatic. Diversity in the karyotypic make-up of the various tumors was the outstanding finding, with no tumor being diploid and no 2 tumors having similar karyotypes. A substantial number of the tumors contained abnormal (marker) chromosomes; however, the number, size and morphology of the marker chromosomes varied from tumor to tumor. No solid tumor was found with a modal number exceeding the tetraploid range; this contrasts with findings in cancerous effusions. The chromosomal numbers of solid, primary tumors published in the literature have been summarized in tabular form. The failure to find diploid primary tumors may be related either to the essentiality of aneuploidy for tumor development and/or maintenance or to the advanced stage of the cancers.
Keywords
KaryotypePloidyCancerAneuploidySolid tumorPathologyChromosomeBiologyLeukemiaPrimary tumorMedicineCancer researchGeneticsMetastasisGene
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Publication Info
- Year
- 1966
- Type
- article
- Volume
- 19
- Issue
- 12
- Pages
- 1879-1890
- Citations
- 58
- Access
- Closed
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Cite This
Kiyomi Yamada,
Nobuo Takagi,
Avery A. Sandberg
(1966).
Chromosomes and causation of human cancer and leukemia. II. Karyotypes of human solid tumors.
Cancer
, 19
(12)
, 1879-1890.
https://doi.org/10.1002/1097-0142(196612)19:12<1879::aid-cncr2820191215>3.0.co;2-z
Identifiers
- DOI
- 10.1002/1097-0142(196612)19:12<1879::aid-cncr2820191215>3.0.co;2-z