Co-expression of renin-angiotensin system genes in human adipose tissue

Abstract

Our findings suggest the presence of a local renin -angiotensin system in human adipose tissue, with adipocytes being an important part of this system, and prompt speculation that this local renin-angiotensin system may be involved in obesity-related disorders, including hypertension and the metabolic syndrome.

Keywords

Adipose tissueRenin–angiotensin systemChymaseInternal medicineEndocrinologyAngiotensin IIAngiotensin receptorAngiotensin-converting enzymeAdipocyteReceptorMedicineBiologyBlood pressureEnzymeBiochemistry

Affiliated Institutions

Freie Universität Berlin DE

Related Publications

Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2

Carlos M. Ferrario , Jewell A. Jessup , Mark C. Chappell +5 more

Background— Angiotensin-converting enzyme 2 (ACE2) has emerged as a novel regulator of cardiac function and arterial pressure by converting angiotensin II (Ang II) into the vaso...

2005 Circulation 1598 citations

Local Potentiation of Bradykinin-Induced Vasodilation by Converting-Enzyme Inhibition in Isolated Coronary Arteries

Wolfgang Auch–Schwelk , C. Bossaller , Matthias Claus +3 more

The interaction of angiotensin-converting enzyme (ACE) inhibitors and bradykinin was investigated in isolated bovine and human coronary arteries. Rings with and without endothel...

1992 Journal of Cardiovascular Pharmacology 33 citations

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Renhong Yan , Yuanyuan Zhang , Yaning Li +3 more

How SARS-CoV-2 binds to human cells Scientists are racing to learn the secrets of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), which is the cause of the pandemi...

2020 Science 5508 citations

Publication Info

Year: 1999
Type: article
Volume: 17
Issue: 4
Pages: 555-560
Citations: 233
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Co-expression of renin-angiotensin system genes in human adipose tissue

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

233

OpenAlex

Cite This

APA Style

                            
                                
                                    Stefan Engeli, 
                                
                                    Kerstin Gorzelniak, 
                                
                                    Reinhold Kreutz
                                
                                et al.
                            
                            (1999). 
                            Co-expression of renin-angiotensin system genes in human adipose tissue. 
                            Journal of Hypertension
                            , 17
                            (4)
                            , 555-560.
                            https://doi.org/10.1097/00004872-199917040-00014
                        

Identifiers

DOI: 10.1097/00004872-199917040-00014