Compassionate Use of Remdesivir for Patients with Severe Covid-19

Jonathan Grein , Norio Ohmagari , Daniel D. Shin , Jonathan Grein , Norio Ohmagari , Daniel D. Shin , George Diaz , Erika Asperges , Antonella Castagna , Torsten Feldt , Gary Green , Margaret L. Green , François-Xavier Lescure , Emanuele Nicastri , Rentaro Oda , Kikuo Yo , Eugenia Quirós-Roldán , Alex Studemeister , John Redinski , Seema Ahmed , Jorge R Bernett , Daniel Chelliah , Danny Chen , Shingo Chihara , Stuart H. Cohen , Jennifer Cunningham , Antonella d’Arminio Monforte , Saad Ismail , Hideaki Kato , Giuseppe Lapadula , Erwan L’Her , Toshitaka Maeno , Sumit Majumder , Marco Massari , Marta Mora-Rillo , Yoshikazu Mutoh , Duc Nguyen , E. Verweij , Alexander Zoufaly , Anu Osinusi , Adam DeZure , Yang Zhao , Lijie Zhong , Anand P. Chokkalingam , Emon Elboudwarej , Laura Telep , Leighann Timbs , Ilana N. Henne , Scott Sellers , Huyen Cao , Susanna K. Tan , Lucinda Winterbourne , Polly Desai , Robertino M. Mera , Anuj Gaggar , Robert P. Myers , Diana M. Brainard , Richard W. Childs , Timothy Flanigan
2020 New England Journal of Medicine 2,887 citations

Abstract

In this cohort of patients hospitalized for severe Covid-19 who were treated with compassionate-use remdesivir, clinical improvement was observed in 36 of 53 patients (68%). Measurement of efficacy will require ongoing randomized, placebo-controlled trials of remdesivir therapy. (Funded by Gilead Sciences.).

Keywords

Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BetacoronavirusCompassionate UseVirologyMedicineCoronavirus InfectionsCoronavirusInternal medicineOutbreakInfectious disease (medical specialty)

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Publication Info

Year
2020
Type
article
Volume
382
Issue
24
Pages
2327-2336
Citations
2887
Access
Closed

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Jonathan Grein, Norio Ohmagari, Daniel D. Shin et al. (2020). Compassionate Use of Remdesivir for Patients with Severe Covid-19. New England Journal of Medicine , 382 (24) , 2327-2336. https://doi.org/10.1056/nejmoa2007016

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DOI
10.1056/nejmoa2007016