Compliance assessment in drug trials: has there been improvement in two decades?

Shiva Jayaraman; Michael Rieder; Doreen Matsui

Abstract

Although the rate of evaluation of compliance in drug trials has improved over the past 25 years, it continues to be examined in less than half of the clinical studies of drug effects in which compliance assessment is required. This rate appears to be similar in paediatric and adult drug studies.

Keywords

MedicineCompliance (psychology)Clinical trialDrugDrug trialPillIntensive care medicineDrug complianceConformity assessmentClinical PracticePatient complianceEmergency medicinePhysical therapyInternal medicinePharmacology

Affiliated Institutions

Related Publications

Pill Count Measures of Compliance in a Drug Trial: Variability and Suitability

Peter Rudd , Richard L. Byyny , Valerie Zachary +4 more

To evaluate pill counts as a compliance measure for drug trials, we followed 121 ambulatory hypertensives selected for good compliance over less than or equal to 12 months. The ...

1988 American Journal of Hypertension 100 citations

Adherence to Medication

Lars Osterberg , Terrence F. Blaschke

The full benefit of many effective medications will be achieved only if patients adhere to prescribed treatment regimens. Unfortunately, applying terms such as "noncompliant" an...

2005 New England Journal of Medicine 7751 citations

Can simple clinical measurements detect patient noncompliance?

R. Brian Haynes , D. Wayne Taylor , D L Sackett +3 more

Measurement of patient compliance is essential if management of low compliance is to be performed efficiently. We assessed the value of several easily obtained clinical assessme...

1980 Hypertension 507 citations

The Language of Medication-Taking

John F. Steiner , Mark Earnest

Medical Writings: Lingua Medica6 June 2000The Language of Medication-TakingJohn F. Steiner, MD, MPH and Mark A. Earnest, MDJohn F. Steiner, MD, MPHDrs. Steiner and Earnest: Univ...

2000 Annals of Internal Medicine 186 citations

Time to stop counting the tablets?

T Pullar , S Kumar , H Tindall +1 more

We attempted to assess compliance using both a pharmacologic indicator (low-dose phenobarbital) and a return tablet count in 225 patients who were taking part in three separate ...

1989 Clinical Pharmacology & Therapeutics 233 citations

Publication Info

Year: 2005
Type: article
Volume: 12
Issue: 3
Pages: e251-3
Citations: 18
Access: Closed

External Links

Citation Metrics

OpenAlex

Cite This

APA Style

                            
                                    Shiva Jayaraman, 
                                
                                    Michael Rieder, 
                                
                                    Doreen Matsui
                                
                            (2005). 
                            Compliance assessment in drug trials: has there been improvement in two decades?. 
                            PubMed
                            , 12
                            (3)
                            , e251-3.