Abstract
Connectionist models are used to explore the relationship between cognitive deficits and biological abnormalities in schizophrenia. Schizophrenic deficits in tasks that tap attention and language processing are reviewed, as are biological disturbances involving prefrontal cortex and the mesocortical dopamine system. Three computer models are then presented that simulate normal and schizophrenic performance in the Stroop task, the continuous performance test, and a lexical disambiguation task. They demonstrate that a disturbance in the internal representation of contextual information can provide a common explanation for schizophrenic deficits in several attention- and language-related tasks. The models also show that these behavioral deficits may arise from a disturbance in a model parameter (gain) corresponding to the neuromodulatory effects of dopamine, in a model component corresponding to the function of prefrontal cortex.
Keywords
Prefrontal cortexConnectionismPsychologyContext (archaeology)CognitionCognitive psychologyStroop effectNeuroscienceSchizophrenia (object-oriented programming)Dopamine
Affiliated Institutions
Related Publications
A computational approach to prefrontal cortex, cognitive control and schizophrenia: recent developments and current challenges
In this chapter we consider the mechanisms involved in cognitive control - from both a computational and a neurobiological perspective — and how these might be impaired in schiz...
Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry.
Patients suffering from schizophrenia display subtle cognitive abnormalities that may reflect a difficulty in rapidly coordinating the steps that occur in a variety of mental ac...
A Parallel Distributed Processing Approach to Automaticity
We consider how a particular set of information processing principles, developed within the parallel distributed processing (PDP) framework, can address issues concerning automa...
Making Working Memory Work: A Computational Model of Learning in the Prefrontal Cortex and Basal Ganglia
The prefrontal cortex has long been thought to subserve both working memory (the holding of information online for processing) and executive functions (deciding how to manipulat...
Cortical organization of voluntary behavior in man.
The research on regional changes in metabolism and blood flow in the human cerebral cortex during physiological activations is reviewed, with special reference to the significan...
Publication Info
- Year
- 1992
- Type
- review
- Volume
- 99
- Issue
- 1
- Pages
- 45-77
- Citations
- 1482
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1482
OpenAlex
Cite This
Jonathan Cohen,
David Servan-Schreiber
(1992).
Context, cortex, and dopamine: A connectionist approach to behavior and biology in schizophrenia..
Psychological Review
, 99
(1)
, 45-77.
https://doi.org/10.1037/0033-295x.99.1.45
Identifiers
- DOI
- 10.1037/0033-295x.99.1.45