Abstract
Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show that Foxp3 , which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4 + regulatory T cells. Furthermore, retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4 + regulatory T cells. Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells.
Keywords
Transcription factorCell biologyControl (management)BiologyChemistryGeneticsComputer scienceGene
MeSH Terms
AnimalsAntigensCDAutoimmune DiseasesCD4-Positive T-LymphocytesCytokinesDNA-Binding ProteinsForkhead Transcription FactorsGastritisImmune ToleranceInflammatory Bowel DiseasesLymphocyte ActivationMiceMiceInbred BALB CMiceSCIDMiceTransgenicMutationReceptorsAntigenT-CellReceptorsInterleukin-2Recombinant Fusion ProteinsSelf ToleranceT-Lymphocyte SubsetsT-LymphocytesT-LymphocytesRegulatoryThymus GlandTransductionGenetic
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Publication Info
- Year
- 2003
- Type
- article
- Volume
- 299
- Issue
- 5609
- Pages
- 1057-1061
- Citations
- 7979
- Access
- Closed
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Cite This
Shohei Hori,
Takashi Nomura,
Shimon Sakaguchi
(2003).
Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>.
Science
, 299
(5609)
, 1057-1061.
https://doi.org/10.1126/science.1079490
Identifiers
- DOI
- 10.1126/science.1079490
- PMID
- 12522256