Abstract
A copper-catalyzed domino reaction of arylidene isoxazolones with 2-(pyridin-2-yl)acetate derivatives under ball-milling conditions has been developed. This protocol provides a rapid and economic approach to constructing a vast variety of biologically important 3-acylindolizines with remarkable functional group tolerance.
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- Year
- 2025
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- article
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Xingwang Hu,
Luan-Ting Wu,
Zeng‐Yang He
et al.
(2025).
Copper-Catalyzed Domino Reaction of Arylidene Isoxazolones with 2-(Pyridin-2-yl)acetate Derivatives under Ball Milling: A Rapid and Economical Synthesis of 3-Acylindolizines.
Organic Letters
.
https://doi.org/10.1021/acs.orglett.5c04683
Identifiers
- DOI
- 10.1021/acs.orglett.5c04683