Copper-Catalyzed Selective N-Sulfenylation of Tryptophan-Containing Peptides

Qi Lu; Han Chu; Hon‐Wah Man; Kun Liu; Cheng‐Ye Yuan

doi:10.1021/acs.orglett.5c04752

Abstract

Site-selective modification of peptides is essential for biomedical research; herein, we develop a versatile strategy for the late-stage functionalization of peptides through copper-catalyzed N-sulfenylation of tryptophan residues. This method is quite compatible with a broad range of functional groups and enables the site-selective formation of a N-S bond at the nitrogen atom of tryptophan without the need for directing groups.

Affiliated Institutions

Qufu Normal University CN

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Publication Info

Year: 2025
Type: article
Citations: 0
Access: Closed

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APA Style

                            
                                    Qi Lu, 
                                
                                    Han Chu, 
                                
                                    Hon‐Wah Man
                                
                                et al.
                            
                            (2025). 
                            Copper-Catalyzed Selective N-Sulfenylation of Tryptophan-Containing Peptides. 
                            Organic Letters
                            
                            .
                            https://doi.org/10.1021/acs.orglett.5c04752

Identifiers

DOI: 10.1021/acs.orglett.5c04752
PMID: 41369085

Data Quality

Data completeness: 77%