CORTICOTROPIN-RELEASING FACTOR (CRF): CENTRAL EFFECTS ON MEAN ARTERIAL PRESSURE AND HEART RATE IN RATS.

Laurel A. Fisher; EAN JRIVIER; Catherine Rivier; Joachim Spiess; Wylie Vale; Marvin R. Brown

doi:10.1210/endo-110-6-2222

Abstract

Intracerebroventricular administration of corticotropin-releasing factor (CRF) produces elevations in mean arterial pressure and heart rate in conscious freely-moving rats. Pretreatment with the ganglionic blocker, chlorisondamine, completely prevents the CRF-induced cardiovascular changes. These results suggest that CRF acts within the brain to stimulate sympathetic nervous activity which in turn influences cardiovascular function.

Keywords

ChlorisondamineInternal medicineEndocrinologyBlood pressureHeart rateMedicineMean arterial pressureGanglionic blockerSympathetic nervous systemReceptorHexamethonium

Affiliated Institutions

Salk Institute for Biological Studies US

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Publication Info

Year: 1982
Type: article
Volume: 110
Issue: 6
Pages: 2222-2224
Citations: 261
Access: Closed

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APA Style

                            
                                
                                    Laurel A. Fisher, 
                                
                                    EAN JRIVIER, 
                                
                                    Catherine Rivier
                                
                                et al.
                            
                            (1982). 
                            CORTICOTROPIN-RELEASING FACTOR (CRF): CENTRAL EFFECTS ON MEAN ARTERIAL PRESSURE AND HEART RATE IN RATS.. 
                            Endocrinology
                            , 110
                            (6)
                            , 2222-2224.
                            https://doi.org/10.1210/endo-110-6-2222
                        

Identifiers

DOI: 10.1210/endo-110-6-2222