Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

Abstract

Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which activate chaperone genes in response to ER stress, also activated JNK, and IRE1 α −/− fibroblasts were impaired in JNK activation by ER stress. The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. Dominant-negative TRAF2 inhibited activation of JNK by IRE1. Activation of JNK by endogenous signals initiated in the ER proceeds by a pathway similar to that initiated by cell surface receptors in response to extracellular signals.

Keywords

Cell biologyEndoplasmic reticulumKinaseUnfolded protein responseSignal transducing adaptor proteinASK1Transmembrane proteinChemistrySignal transductionReceptorProtein kinase ABiologyMitogen-activated protein kinase kinaseBiochemistry

Affiliated Institutions

New York University US

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Publication Info

Year: 2000
Type: article
Volume: 287
Issue: 5453
Pages: 664-666
Citations: 2920
Access: Closed

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APA Style

                            
                                
                                    Fumihiko Urano, 
                                
                                    Xiao-Zhong Wang, 
                                
                                    Anne Bertolotti
                                
                                et al.
                            
                            (2000). 
                            Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1. 
                            Science
                            , 287
                            (5453)
                            , 664-666.
                            https://doi.org/10.1126/science.287.5453.664
                        

Identifiers

DOI: 10.1126/science.287.5453.664