Keywords
BiologyCpG siteDNA methylationEpigenetics of physical exercisePromoterDifferentially methylated regionsDNADNA replicationGeneticsCell biologyGeneGene expression
Affiliated Institutions
Related Publications
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here, we report the first genome-scale study of epigenomic dynamics durin...
De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines.
CpG dinucleotides are unevenly distributed in the vertebrate genome. Bulk DNA is depleted of CpGs and most of the cytosines in the dinucleotide in this fraction are methylated. ...
A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci
CpG islands (CGIs) are dense clusters of CpG sequences that punctuate the CpG-deficient human genome and associate with many gene promoters. As CGIs also differ from bulk chromo...
An expansive human regulatory lexicon encoded in transcription factor footprints
Regulatory factor binding to genomic DNA protects the underlying sequence from cleavage by DNase I, leaving nucleotide-resolution footprints. Using genomic DNase I footprinting ...
Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population
Age-related changes in DNA methylation have been implicated in cellular senescence and longevity, yet the causes and functional consequences of these variants remain unclear. To...
Publication Info
- Year
- 1999
- Type
- review
- Volume
- 9
- Issue
- 17
- Pages
- R661-R667
- Citations
- 226
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
226
OpenAlex
Cite This
Francisco Antequera,
Adrian Bird
(1999).
CpG islands as genomic footprints of promoters that are associated with replication origins.
Current Biology
, 9
(17)
, R661-R667.
https://doi.org/10.1016/s0960-9822(99)80418-7
Identifiers
- DOI
- 10.1016/s0960-9822(99)80418-7