Abstract
Rapidly growing and apparently permanent cultures were established from hematopoietic cells from two staff members with no known malignant disease. The cell lines were similar to those derived from leukocytes from the peripheral blood of patients with malignancies of either hematopoietic or nonhematopoietic origin and to the lymphoblastoid cell lines derived from Burkitt's lymphoma. Both cell lines contained a herpetic-like virus (leukovirus), produced immunoglobulins, and grew rapidly in various suspension cultures.
Keywords
MedicineLymphomaCell cultureHaematopoiesisVirusLymphoblastVirologyPeripheral bloodAntibodyHematopoietic cellImmunologySuspension cultureStem cellCell biologyBiology
Related Publications
Expansion<i>in vitro</i>of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability
Elucidation of mechanisms that regulate hematopoietic stem cell self-renewal and differentiation would be facilitated by the identification of defined culture conditions that al...
The A-myb gene is preferentially expressed in tonsillar CD38+, CD39-, and sIgM- B lymphocytes and in Burkitt's lymphoma cell lines.
Abstract The A-myb gene is structurally related to the c-mby proto-oncogene, a transcription factor involved in the regulation of hemopoietic proliferation and differentiation. ...
Propagation of human blastic myeloid leukemias in the SCID mouse
Abstract Existing in vitro culture technology does not permit the routine propagation of most human myeloid leukemias. Previous work has shown the usefulness of mice with severe...
Stromal cell-associated hematopoiesis: immortalization and characterization of a primate bone marrow-derived stromal cell line
Abstract An elucidation of the interaction between the bone marrow microenvironment and hematopoietic stem cells is critical to the understanding of the molecular basis of stem ...
Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells
Bone marrow stroma provides the microenvironment for hematopoiesis and is also the source of mesenchymal progenitors (mesenchymal or marrow stromal cells [MSC]) that may serve a...
Publication Info
- Year
- 1967
- Type
- article
- Volume
- 199
- Issue
- 8
- Pages
- 519-519
- Citations
- 775
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
775
OpenAlex
Cite This
George E. Moore
(1967).
Culture of Normal Human Leukocytes.
JAMA
, 199
(8)
, 519-519.
https://doi.org/10.1001/jama.1967.03120080053007
Identifiers
- DOI
- 10.1001/jama.1967.03120080053007