Abstract
Summary The effects of intradermally injected prostaglandins (PGs) E 1 , E 2 , F 1α and F 2α have been examined in the rat and in man. PGE 1 and PGE 2 caused an increase in local vascular permeability in rat skin; their potency was comparable with that of other putative mediators of inflammation (histamine, bradykinin, and 5 ‐hydroxytryptamine), but PGF 1α and PGF 2α were only slightly active even at a dose of 1 μg. Prior administration of mepyramine and methysergide, or depletion of skin mast cell amines with compound 48/80, indicated that PGE 2 exerted its permeability effect in the rat by a release of mast cell amines. Nanogramme doses of PGE 1 and PGE 2 or microgramme doses of PGF 1α and PGF 2α injected intradermally into the human forearm induced weal and flare responses. It is concluded that prostaglandins E 1 and E 2 can act as intermediates in the production of hyperaemia and oedema resulting from cell damage in the rat and man.
Keywords
HistamineMethysergideMepyramineChemistryBradykininProstaglandin EIntradermal injectionVascular permeabilityEndocrinologyMast cellProstaglandinInternal medicineMetiamidePharmacologyMedicineImmunologyBiochemistryAntagonistReceptorHistamine H2 receptor
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Publication Info
- Year
- 1971
- Type
- article
- Volume
- 41
- Issue
- 1
- Pages
- 49-56
- Citations
- 333
- Access
- Closed
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Cite This
Pearl Crunkhorn,
A.L. Willis
(1971).
Cutaneous reactions to intradermal prostaglandins.
British Journal of Pharmacology
, 41
(1)
, 49-56.
https://doi.org/10.1111/j.1476-5381.1971.tb09934.x
Identifiers
- DOI
- 10.1111/j.1476-5381.1971.tb09934.x